MRE11 and gastric cancer: Not only are the genes of mismatch repair pathway found to be altered, there are numerous other genes belonging to the category of DNA repair/chromatin structure regulation (CHK1, MRE11, RAD50), signal transduction (IGFIIR, TGFβRII), transcriptional regulation (E2F4), miRNA regulation (APAFI), and apoptosis (caspases, BCL10) that are found to be mutated in gastric cancer patients having MSI [25].