In a study by Yu et al [60] out of 17 gastric cancer cell lines studied, Dkk-3 inactivation was found in 12 (70.6%) of them and this inactivation was correlated to promoter methylation that could be restored by treatment with demethylation agent like 5-aza-2’-deoxycytidine in combination with trichostatin A. The study also demonstrated methylation of Dkk-3 as an independent prediction marker in gastric cancer and related to poor disease survival in most aggressive type gastric cancer [60]. This evidence concerns the gene DKK3 and gastric cancer.