In another experimental analysis done by Giovanni Corso and his group, they found 55.6% of MSI GC cases to possess a mutation in at least either one of these genes- EGFR, KRAS, BRAF, PIK3CA, or MLK3- which are members of the mitogen-activated protein kinase (MAPK) cascade and phosphatidylinositol 3-kinase (PI3K) survival pathways [32]. The gene discussed is PIK3CA; the disease is gastric cancer.