Chemotherapy generally induces apoptosis and damage to the DNA in the progressing tumours, i.e., inactivation of the apoptotic genes like Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) and death-associated protein kinase (DAPK) by methylation generates chemo-resistance in gastric cancer patients [54]. The gene discussed is BNIP3; the disease is neoplasm.