KLK3 and Familial prostate cancer: According to the Prostate Cancer Intervention Versus Observation Trial (PIVOT) [3], men with low risk disease defined as a prostate specific antigen (PSA) ≤ 10ng/mL, a Gleason score ≤ 6, and T stage 1 or 2a had no difference in mortality, i.e., in terms of all-cause mortality and prostate cancer specific mortality.