In our previous reports in a general population with mild cognitive impairment and AD, the differential sensitivity and specificity of Aβ-42 and tau between HC and non-DS AD were approximately 0.9 (0.88–0.97), using thresholds of 16.33 pg/ml for Aβ-42 and 23.89 pg/ml for tau. This evidence concerns the gene MAPT and Cognitive impairment.