KCNA1 and neoplasm: For example, low levels of KCNA1 correlate with increased aggressiveness of primary breast tumors9; repression of KCNA5 plays a role in Ewing sarcoma and neuroblastoma10; blocking the KCNK9 channel inhibits tumor growth and metastasis11; Kir2.2 was overexpressed in human cancer12; high Kv1.3 and Kv1.5 expression levels are markers of breast, colon, and prostate cancer13; overexpression of Kv1.1 is detected in medulloblastoma14; elevated Kv11.1 expression indicates blood cancer15.