The ROC curve (Figure 2) presented thepredictive value of the S100β level in diagnosing SVD with cognitivedysfunction, in which the area under curve (AUC) was 0.845, 95% confidenceinterval (CI) was 0.786–0.905, the sensitivity was 71.74%, specificitywas 88.75%, diagnosis threshold was 1.10, positive predictive value was88.00%, and negative predictive value was 88.00%. The gene discussed is S100B; the disease is snowflake vitreoretinal degeneration.