ENPP2 and cancer: As shown in Fig. 4A–F, significant strong correlations were observed between the total LysoPA levels and the total ATX (r = 0.728, P < 0.001) and moderate correlations were observed between the total LysoPA and classical ATX or novel ATX levels (r = 0.664, P < 0.001 and r = 0.535, P = 0.009, respectively) in ascites from patients with cirrhosis, while only weak to moderate correlations were observed in ascites from patients with cancer.