APP and Hypercholesterolemia: As mentioned above APP/ε2 mice also develop hypercholesterolemia and atherosclerosis, hence increased susceptibility to cerebral microhemorrhages and in particular high incidence of large hemosiderin deposits in APP/ε2 mice associated with immunotherapy can be a resultant of prevalent VAβ pathology, anti-Aβ mAb effect, and cerebrovascular risk factors all cooperatively compromising vascular wall integrity.