Notably, regulation of some genes indicated potential parasite manipulation to facilitate infection; these included the major histocompatibility complex (MHC) class II (MHC-II) related genes that were repressed, the acute phase protein LBP which was downregulated, modulation of the expression of the transcriptional repressor Bcl6 over the course of infection, upregulation of the transcription factor Smad6, repression of genes involved in the oxidative burst, and finally, modulation of the regenerative response related genes (Brca1 and Blm). This evidence concerns the gene SMAD6 and infection.