IARS1 and adenoma: Comparing the expression of TKTL1 among the various tumors, it is also worthy of note that the simple type adenomas and carcinomas tend to show a higher expression compared to the complex forms, whether they are benign (IRS = 1) and malignant (IRS = 1), indicating therefore a predominant role of TKTL1 in the epithelial cells compared to the myoepithelial component (P < 0.001).