Activation of oncogenic processes such as increased activity of the oncogenes c-Myc and Bcl-2 and decreased activity of the tumor suppressor genes p53 and PTEN may strengthen the survival responses of cells resisting cell death, and the immunological cytotoxicities from tumor-infiltrating immune suppressive cells are speculated to be decreased and/or stopped [33]. Here, TP53 is linked to neoplasm.