Despite cooperating with tumor-infiltrating immune cells harboring the immunosuppressive activities such as tumor-associated macrophages (TAMs), cluster of differentiation (CD) 4+ CD25+ forkhead box P3 (FOXP3)+ regulatory T cells (Treg), and myeloid-derived suppressor cells (MDSCs) [7], it is unclear whether oncogenic processes are also involved in the immune escape of cancer cells by inducing a cellular immune tolerance in response to immune recognition and activation. This evidence concerns the gene FOXP3 and cancer.