As reported by previous studies on a defective response of MHC I expression in IFN-γ-resistant AGS cells [1, 2], future studies are needed to determine whether targeting SHP2 can reverse the lack of immunogenicity in cancer cells and whether the IFN-γ-induced MHC class I and cytotoxic factors related to the CTL responses can be overturned. This evidence concerns the gene PTPN11 and cancer.