IFNG and neoplasm: Under immunosurveillance, immune cells such as T cells, natural killer (NK) cells, NKT cells, γδ T cells, and macrophages functionally translocate into tumor sites and trigger anticancer immunity by secreting several cytotoxic molecules including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, perforin, granzyme, CD95 ligand (FasL), and TNF-related apoptosis-inducing ligand (TRAIL) [21, 22, 69].