Consistent with these findings, we found that the benefit of regular aspirin use on CRC risk was most pronounced in individuals with T alleles of rs6983267, [43] an 8q24 CRC susceptibility single nucleotide polymorphism [44–46] that we have shown is associated with impaired β-catenin binding to TCF4 adjacent to MYC [47]. Here, MYC is linked to colorectal carcinoma.