TGFBR2 and neoplasm: Hembruff et al. showed that TGFβR2 KO in fibroblasts increases CCL2 production and when these fibroblasts are co-implanted with 4T1 cells, there is enhanced primary tumor growth and metastases as compared to 4 T1 cells co-implanted with TGFβR2 expressing fibroblasts [35].