The relationship between obesity-induced inflammation and brain plasticity, particularly in the hippocampus and frontal cortex, is highlighted by the enhanced astrocytic and microglial activation and increased mRNA levels of IL-1β, IL-6, and TNF-α in the cortex and the hippocampus of EMD mice compared to the control. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.