Baseline levels of serum IL-22 levels (median and 25th/75th percentiles) were 6.45 (1.95; 11.80) pg/ml for cases and 6.28 (1.95; 12.35) pg/ml for non-cases (age and sex-adjusted P = 0.744, Additional file 1: Table S4), which was reflected by an OR (95% CI) per doubling of serum IL-22 (i.e. twofold increase in baseline IL-22) for incident type 2 diabetes of 1.02 (0.85; 1.23) (Table 3). The gene discussed is IL22; the disease is type 2 diabetes mellitus.