For OS, the significant inferior prognostic factors included the male sex, history of alcohol consumption, ALT, AST, TBil, ALB, ALP, GGT, WBC, NC, LC, NLR, Cr, PTA, AFP ≥ 400 ng/mL, tumor number ≥ 3, tumor diameter ≥ 5 cm, lymph node metastasis, and portal vein involvement (p < 0.05). This evidence concerns the gene AFP and metastatic malignant neoplasm in the lymph nodes.