The proposed nomogram included three liver function indices (AST, GGT, PTA), five tumor-related indicators (AFP, tumor number and size, lymph node metastasis, and portal vein involvement), and two inflammatory indices (WBC, NLR), which performed well in predicting the survival outcome of HCC patients, and the prediction was supported by the C-index (0.82 and 0.78 for the primary and validation cohorts, respectively) and the calibration curves. Here, AFP is linked to neoplasm.