For example, IGFBP-2 induction has been shown to activate cell invasion, and increased levels of IGFBP-2 have been reported in ovarian tumour tissues and serum [21], as well as increased IGFBP-3 mRNA expression in HNSCC compared to healthy tissue [20]. The gene discussed is IGFBP3; the disease is head and neck squamous cell carcinoma.