Given this different tumours appearance, as well as the important role proposed for MET in tumour-tissue interaction and in cell migration/metastasis, we analysed stromal compartment markers, namely collagen deposition (Masson’s trichrome), anti-smooth muscle actin staining (α-SMA), a marker of activated fibroblasts and cd31 staining to assess for neovascularization, before and after SGX523 treatment. This evidence concerns the gene ACTA1 and neoplasm.