To assess if EGFR-MET interaction is modified by EGFR mutations, we first generated two novel cell lines by modification of the NCI-H1975 lung adenocarcinoma cell line that harbours L858R and T790M (L858R/T790M) mutant EGFR (to be referred to from here on as H1975L858R/T790M). This evidence concerns the gene MET and lung adenocarcinoma.