Tumor invasion was associated with increased tumor size (OR = 84.33, 95% CI = 12.84–554.0, P < 0.001), high MVD (OR = 15.96, 95% CI = 3.99–63.85, P < 0.001), high PI (OR = 27.50, 95% CI = 6.06–124.8, P < 0.001), and upregulation of COX-2 (OR = 5.18, 95% CI = 1.48–18.19, P = 0.010), VEGF-A (OR = 15.96, 95% CI = 3.99–63.85, P < 0.001), and HO-1 (OR = 6.08, 95% CI = 1.72–21.50, P = 0.005) expression. The gene discussed is HMOX1; the disease is neoplasm.