CD276 and pneumococcal meningitis: By using a murine model of pneumococcal meningitis, we previously demonstrated that B7-H3 strongly augmented S. pneumoniae-induced inflammatory response with exacerbated BBB disruption and aggravated brain injury, which occurs in a TLR2-dependent manner as B7-H3 almost completely lost its amplifying action on S. pneumoniae-induced inflammatory response in TLR2-deficinet mice [13].