Recently, investigators have highlighted four cases of SMARCB1-deleted neoplasms of various morphologies (myoepithelial carcinoma, extrarenal rhabdoid tumour, poorly differentiated chordoma and proximal-type epithelioid sarcoma) that also demonstrated EWSR1 abnormalities with FISH, which had initially led to misinterpretation of these as EWSR1-rearranged tumours (Huang et al, 2016). The gene discussed is EWSR1; the disease is chordoma.