Care should therefore be taken in the interpretation of FISH for EWSR1 rearrangement with INI1-deficient neoplasms, and in general the FISH patterns for these tumours have been complex, differing from the more uniform and simple split signals of typical EWSR1-rearranged neoplasms (Huang et al, 2016). The gene discussed is EWSR1; the disease is neoplasm.