First observed to be rearranged in Ewing sarcoma (Aurias et al, 1983), the Ewing sarcoma breakpoint region 1 gene (EWSR1) on chromosome 22q12 encodes a 656 amino acid nuclear protein including a carboxy-terminus 87-amino acid RNA-binding domain (exons 11–13) involved in protein–RNA binding, transcription and RNA metabolism (Fisher, 2014). The gene discussed is EWSR1; the disease is Ewing sarcoma.