In that context, it is also remarkable that DISC1 as a single factor is able to both regulate dopamine neuroanatomy as well as parvalbumin-positive interneuron placement in cortical layers.115 Third, elevated dopamine synthesis capacity is the other aspect of presynaptic dopamine dysregulation widely linked to schizophrenia and people at risk of schizophrenia.36, 37, 116 Thus, future work should test if DISC1 alterations affect this aspect of presynaptic dopamine function in humans. This evidence concerns the gene PVALB and schizophrenia.