With regards to the first point, recent studies suggest that DISC1 alterations interact with stress to impact on dopaminergic neurons during adolescence.51, 86 These findings are in line with evidence showing that adolescence is a critical time life for the development of psychotic disorders including schizophrenia.87 With regards to the second point, a possible mechanism underlying increased dopamine levels in the nucleus accumbens could be a reduction in cortical parvalbumin-positive interneurons. This evidence concerns the gene PVALB and psychotic disorder.