It should be noted that DISC1 is also associated with affective disorders including major depression.101, 102 The implications of the findings for this association remains unclear, as human PET studies have shown decreased dopamine synthesis capacity in patients with major depression particularly in individuals with reduced affect or psychomotor slowing symptoms103, 104, 105 and some endophenotypes such as anhedonia are thought to be underlined by dopamine function.106, 107. The gene discussed is DISC1; the disease is major depressive disorder.