DISC1 and schizophrenia: Screening for DISC1 polymorphisms may be one way to assess this as some polymorphisms have been associated with different neuronal functions and with treatment-resistant schizophrenia.109, 110, 111 As it has been demonstrated that single-nucleotide polymorphisms of DISC1-interacting genes are overrepresented in schizophrenia,112 the use of a DISC1-interactome polygenic risk score might also be a complementary approach to stratify the risk associated with a specific signalling pathway or response to treatment.