In a recent paper, we investigated the effect of glucose deprivation on tau metabolism using a neuronal cell line, and showed that under this experimental condition cells manifest an increase in tau phosphorylation via the activation of the p38 MAPK.10 On the basis of our in vitro studies we predicted that the increase in tau phosphorylation in an in vivo model of chronic energy depletion would be ultimately responsible for cognitive impairments and synaptic dysfunction. This evidence concerns the gene MAPT and Cognitive impairment.