Anti-tumor properties of HPßCD-HET0016 resulted in decreasing proliferation, hypoxia, migration, stemness, and vasculatures in glioma by altering the balance of pro-angiogenic and anti-angiogenic balance, PI3K/Akt, p38/MAPK and inflammation pathways (Summary model in Fig. 9). Here, AKT1 is linked to central nervous system cancer.