We also measured the presence of 20-HETE and MGMT in different glioma cells (GL261, U251, HF2303 and GBM811) and GBM811 showed comparatively lower amount of 20-HETE and methylguanine DNA methyltransferase (MGMT) levels (Supplementary Figure 5 and 6), which may indicate better treatment results following HET0016, radiation and TMZ in GBM811 PDX model16, 17. Here, MGMT is linked to central nervous system cancer.