In UCEC, ∼66% of tumours have PTEN inactivating mutations, ∼50% have PIK3CA activating mutations and ∼35% have a comutation of PTEN and PIK3CA. Figure 5a shows 134 TFs associated with somatic aberrations in PTEN or PIK3CA in BRCA, HNSC or UCEC. The gene discussed is PTEN; the disease is neoplasm.