Many of the novel SNPs we found to be associated with PSA levels are intronic, including SNPs in genes in pathways involved in cellular signalling, growth, and differentiation (PHF19, TXLNG, RAI2)46, 47, 48, and in the development of hematologic malignancies (BCLL1A and DLEU1)49, 50. This evidence concerns the gene DLEU1 and hematologic disorder.