rs6457327 is located near the HLA-C in the HLA class I region14; rs10484561 and rs2647012 are located in HLA class II region13, which are in high linkage disequilibrium with the extended haplotypes DRB1*01:01-DQA1*01:01-DQB1*05:01 and DRB1*15-DQA1*01-DQB1*06:0216; rs9271100 is located in HLA class II region and was associated with numerous autoimmune disease since its first discovery through the GWAS of systemic lupus erythematosus (SLE)17. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.