HLA-C and systemic lupus erythematosus: rs6457327 is located near the HLA-C in the HLA class I region14; rs10484561 and rs2647012 are located in HLA class II region13, which are in high linkage disequilibrium with the extended haplotypes DRB1*01:01-DQA1*01:01-DQB1*05:01 and DRB1*15-DQA1*01-DQB1*06:0216; rs9271100 is located in HLA class II region and was associated with numerous autoimmune disease since its first discovery through the GWAS of systemic lupus erythematosus (SLE)17.