VEGFA and age-related macular degeneration: The development of advanced neovascular choroidal changes accounts for more than 80% of severe visual disability caused by AMD.2 Landmark studies have revolutionized care by demonstrating that intravitreal anti-vascular endothelial growth factor (anti-VEGF) can lead to far better visual function than has ever previously been possible,3,4 but the condition still involves a high clinical and socioeconomic burden with real-world outcomes currently far inferior to those of the landmark studies.5