Considering the functional deficiencies of iNKT cells in CML-CP patients at diagnosis and the fact that IL-4 production by iNKT cells was partially restored in patients having achieved CCyR after TKI therapy (22), we surmised that innate CD8(+) T cells might also be altered during CML and be restored in CML patients with CCyR. This evidence concerns the gene IL4 and chronic myelogenous leukemia, BCR-ABL1 positive.