Moreover, expression of PLZF and Eomes in iNKT cells and innate CD8(+) T cells, respectively, were both found to be reduced in patients at CML diagnosis, and reversed after disease remission, as were innate CD8(+) T cells in terms of both number and functions. The gene discussed is CD8A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.