Finally, both IFN-γ after IL-12 + IL-18 stimulation and cytolytic activity of classical NK cells were likewise decreased in CML-CP patients [7.0% ± 2.0 (n = 8) and 34.3% ± 11.5 (n = 5), respectively] as compared to HD [25.8% ± 3.9 (n = 15) and 65.9% ± 8.1 (n = 6), respectively] (Figure S2 in Supplementary Material). Here, IL18 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.