Importantly, in these conditions, IFN-γ expression in response to IL-12 + IL-18 was partially restored in the innate CD8(+) T cell compartment from CML-IM patients (7.7% ± 2.3; n = 6 vs. 0.7% ± 0.1; n = 5 in CML-CP patients) relative to HD (24.8% ± 1.2; n = 6) (Figure 3B), while cytolytic activity, measured as frequencies of CD107a-expressing cells in KIR/NKG2A(+) Eomes(+) CD8(+) CD3(+) cells, returned to normal (27.3% ± 8.3; n = 6 vs. 6.8% ± 4.1; n = 5 in CML-CP patients), relative to HD (26.4% ± 6.2; n = 6) (Figure 3C). The gene discussed is KIR3DL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.