Moreover, p53 signaling target genes, such as the p53 effector TP53I3, RRM2B, and DDB2 (which play roles in DNA damage repair) and SENS1 (a protein mediating the tumor-suppressive effect of p53 by inhibiting mechanistic target of rapamycin), were increasingly upregulated with prolonged exposure. This evidence concerns the gene RRM2B and neoplasm.