In liver cancer, accumulating evidence has demonstrated the existence of a small subset of cancer cells with stem cell properties (self-renewal and differentiation) and several CSC markers have been identified, including CD133, CD90, CD44, oval cell marker OV6, EpCAM, CD13, CD24, DLK1, α2δ1, ICAM-1, CD47, Lgr5, and keratin19 [4–16]. This evidence concerns the gene EPCAM and liver cancer.