APOE and Alzheimer disease: Results from augmenting studies suggest an increase specifically in the pool of oligomeric Aβ in FAD-Tg mice expressing APOE ε4, in synaptosome-enriched preparations from APOE ε4 carriers and in APOE ε4 versus APOE ε3 carrier AD patients, of which the former AD patients exhibit higher levels of oligomeric Aβ surrounding amyloid plaques [8].