IL1RAP and acute myeloid leukemia: For example, it has been revealed that CD90 and CD117 are deficient in AML LSCs [39], while CD123 [42, 48], TIM3 [44, 49], CD47 [50, 51], CD96 [52], CLL-1 [53, 54], and IL-1 receptor accessory protein (IL1RAP) [55] are highly expressed in AML LSCs.