We have identified five excellent PD gene candidates (GPATCH2L, UHRF1BP1L, PTPRH, ARSB, and VPS13C), harboring homozygous or compound heterozygous LoF variants in PD exomes, demonstrating functional interactions with mitochondrial and/or α-synuclein-mediated mechanisms, and supported by evidence of replication in independent human datasets. Here, ARSB is linked to Parkinson disease.