NRIP2 and colorectal cancer: Gene set enrichment analysis (GSEA) also showed that in colorectal cancer cells expressing high levels of NRIP2, the alteration of the mRNA expression profiles was similar to that observed with low- and intermediate-CpG-density promoters bearing the histone H3 trimethylation marker at K4 and K27 (H3K4me3 and H3K27me3) in embryonic stem cells (ES) and induced pluripotent cells (iPS) (Fig. 2i).