In addition to the activation of the Wnt pathway by NRIP2/RORβ/HBP1, NRIP2 is also associated with DNA mismatch repair in colorectal cancer cells, and RORβ may be correlated with tumorigenesis and tumor stages (Additional file 2), suggesting that the NRIP2/RORβ/HBP1 pathway is also involved in other biological processes. The gene discussed is RORB; the disease is colorectal cancer.