TNFRSF10B and neoplasm: However, DR5 expression was significantly increased in tumor tissues when lovastatin was given through local peri-tumoral administration (Fig 4F–4H), while the expression was not altered in the normal tissue such as liver (Fig 4F and 4G), indicating that local peri-tumoral administration of lovastatin selectively induced DR5 expression in tumor tissue but not in the normal tissue.