When we analyzed subjects with ischemic heart disease (n = 168) and those without (n = 188) separately in model 3, the odds ratio of the highest suPAR tertile for low LVEF and BNP ≥ 300 pg/mL was 15.5 (95% CI 3.33–72.2, P<0.001) and 9.66 (95% CI 0.94–99.5, P = 0.057), respectively (ischemic heart disease), and 1.77 (95% CI 0.30–10.30, P = 0.53) and 13.45 (95% CI 2.05–88.23, P = 0.007), respectively (no ischemic heart disease). Here, NPPB is linked to coronary artery disorder.