Consistently, Atg4B mRNA level was higher in HCC tissues than that in normal liver tissues (0.86±0.1352, vs1.098±0.2247, P<0.001, n=22) in Roesser liver database (Compendia Biosciences, www.oncomine.org) (Figure 6b) and TCGA liver cancer RNAseq (IlluminaHiSeq; N=371) data set (https://genome-cancer.ucsc.edu). Here, ATG4B is linked to hepatocellular carcinoma.