Our previous work showed that phosphorylation of PRH by CK2 abolishes the DNA-binding activity of PRH.12 We showed that this prevents PRH from regulating transcription and abrogates the effects of PRH on the proliferation of leukaemic cells.13 Here we have shown that nuclear pPRH is increased in BPH and prostatic adenocarcinoma compared with normal tissue and that pPRH levels are increased in prostate cancer cell lines compared with normal immortalised prostate epithelial cells. This evidence concerns the gene HHEX and prostate cancer.