CASP8 and ovarian neoplasm: While Bim is long recognized for its antagonizing role in the integrin-mediated tumor cell survival,35 it is strongly induced by JQ1, according to recent studies.36 Thus, VS-6063 and JQ1 may synergistically inhibit ovarian tumor cell survival largely by mitigating the integrin–FAK-dependent cell survival or activation of the Bim/caspase 8-linked apoptotic process.