In addition, JQ1 is implicated in suppressing the activation of Twist1, a strong driver of cell invasion and extracellular matrix remodeling in metastatic ovarian cancer.43, 44 Collectively, the treatment with the VS-6063 and JQ1 combination appears to be not only effective in disrupting tumor cell survival but also have a broad functional impact, including the effect on tumor cell invasion or metastatic progression. Here, TWIST1 is linked to neoplasm.