In comparison, SK-OV-3, a low-grade ovarian tumor line, had the least sensitivity (Figure 1c), consistent with a prior study.26 Furthermore, the specific effect of VS-6063 on the integrin-induced FAK activation was also validated, as OVC-5 cells exhibited a marked decrease in the sensitivity to this inhibitor upon the stable knockdown of β1 integrin (Figure 1b). Here, PTK2 is linked to ovarian neoplasm.