In fact, the integrin–FAK signaling axis has been consistently linked to cell motility, invasion and colonization during ovarian cancer metastasis.4 Also, JQ1 confers an inhibitory role in tumor cell invasion.43 In line with this notion, a number of HGSOC cell lines that confer strong invasive potential and EMT phenotype, including OVCAR-8, OVCAR-433 and OVCAR-5, appear to express high levels of active FAK and Myc (Figures 6 and 8). Here, PTK2 is linked to ovarian carcinoma.