In addition, COX2 inhibitor, Meloxicam, suppresses the growth of invasive orthotropic bladder cancer (established by inoculating KU-7 low-grade papillary bladder cancer cells into the urinary bladder of nude mice) correlating with dowregulation of CK2α protein and phospho-AKT level [62]. Here, AKT1 is linked to urinary bladder cancer.