Inhibition of CK2α, by siRNA or CK2α inhibitor emodin, led to inhibition of colorectal carcinoma cell proliferation, G0/G1 cell cycle phase arrest, inhibition of cell division, increase in p53/p21 expression, downregulation of c-myc, and decreased cell motility and invasion [100]. The gene discussed is MYC; the disease is colorectal carcinoma.