Indeed, CK2 inhibition with DRB leads to increased TRAIL-induced apoptosis in colon carcinoma cells, correlating with increased TRAIL-induced death-inducing signaling complex (DISC) formation, caspase-8 cleavage, and Bid cleavage, leading to proapoptotic factor release from the mitochondria. This evidence concerns the gene CASP8 and colon carcinoma.