The target of CK2 action may be PTEN as CK2 can phosphorylate PTEN [32], CK2α overexpression correlates with PTEN phosphorylation in T-ALL primary cells, inhibition of CK2 led to increased PTEN activity, and subsequently decreased Akt phosphorylation [182,187]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.