ACO1 and Hepatitis: After eight weeks of HF-EFr consumption, reduced glycogen storage in HF-EFr group was associated with increased evidence of oxidative stress, as manifested by increased expression of Cyp2e1 and Aco1. Consumption of HFD or high-sucrose-diet for one week resulted in hepatic IR, and after 5 weeks these diets produced both hepatic and peripheral (skeletal muscles) IR [50].