Additionally, pretreatment with NAC (i.p., 150 mg/kg given 30 min before) increased HIF-1α protein levels and its target proteins EPO and glucose transporter 3, in the ipsilateral hemispheres of rodents subjected to 90 min MCAO and 24 h reperfusion, indicating that HIF-1α might take part in NAC ́s protection in stroke [121]. This evidence concerns the gene EPO and stroke disorder.