WNT5A and posterior cortical atrophy: To test whether activation of non-canonical WNT signaling modulates enzalutamide sensitivity, they ectopically expressed the ligands for non-canonical WNT signaling, including WNT4, WNT5A, WNT7B, or WNT11, in LNCaP PCa cells, which express these ligands at low endogenous levels.