AR and posterior cortical atrophy: While WNT/β-catenin pathway is repressed by AR in the androgen-dependent LNCaP cell line, upon repression of AR activity or in the androgen-independent subline of LNCaP cells (LNCaP-abl), the WNT/β-catenin responsive transcription appeared to be largely activated, suggesting a likely role of WNT signaling in PCa progression to CRPC [96] (Figure 4B).