AR and posterior cortical atrophy: To add another layer of the complexity of interaction between AR and WNT/β-catenin signaling, it was shown that when PCa cells had been adapted to the low androgen environment (e.g., upon ADT), β-catenin could act as a co-activator of AR as well to enhance AR transcriptional activity in the presence of androstenedione, a weaker adrenal androgen remaining present in CRPC patients [239,241,242,243].