Thus, it seems the effect of AR signaling on WNT/β-catenin signaling is PCa stage-dependent: it suppresses WNT/β-catenin signaling in hormone-naïve PCa, but in CRPC, both AR signaling and WNT/β-catenin signaling work together to positively support each other and to control a unique set of genes for sustaining CRPC cells (Figure 4). The gene discussed is AR; the disease is posterior cortical atrophy.