LMNA and Hutchinson-Gilford progeria syndrome: In Hutchinson-Gilford progeria syndrome (HGPS), the most common mutation is a de novo missense mutation in exon 11 of the LMNA gene, which results in the creation of an abnormal splice donor site and expression of a 50-amino acid region near the carboxy terminus to result in a truncated protein, permanently farnesylated prelamin A, termed progerin [81,82].