Previously, deguelin alone was reported to induce apoptosis via AKT signaling inhibition, autophagy, and CDK4/Survivin degradation at high doses (50 or 100 μM) [20] and to suppress invasive ability at a low dose (0.1 μM) in HNSCC cells [23]. Here, AKT1 is linked to head and neck squamous cell carcinoma.