MTOR and head and neck squamous cell carcinoma: On the other, in some cases, it has been reported that the combination of erlotinib (EGFR TKI) and everolimus (mTOR inhibitor) did not show significant benefits in unselected patients with platinum-resistant metastatic HNSCC [26], and that six out of 12 patients administered erlotinib and temsirolimus (mTOR inhibitor) withdrew within six weeks due to toxicity or death due to poor tolerance, prompting early closure of the trial [27].