Application of dTBP2 inhibited the mRNAs levels of proinflammatory cytokines such as IL-6 well as Th2-related cytokines/chemokines associated with pathogenesis of atopic dermatitis including IL-4, IL-5, IL-13, TSLP, MCD, and TARC (Figure 4). The gene discussed is IL4; the disease is atopic eczema.