In another model, Treg lost their ability to suppress development of autoimmune gastritis after anti-CD25 depletion and repopulation [83,84,85], suggesting that reduced Treg function could be relatively common when Tregs are transiently depleted, In addition to having reduced suppressive function, Treg repopulating the spleens of anti-CD25 or Foxp3-DTR mice differed phenotypically from endogenous Treg in B−/− mice, having surface markers like those of the less functional Treg in untreated WT mice [65]. This evidence concerns the gene FOXP3 and autoimmune gastritis.