This could be particularly detrimental for peripheral and central autoimmune diseases that have as their molecular targets nodal antigens including NF186 (Mathey et al., 2007; Ng et al., 2012; Uncini et al., 2013) resulting in a 'double-hit': disruption of nodal neurofascin and paranodal junction cytoskeletons. The gene discussed is NFASC; the disease is autoimmune disease.