To estimate the effects of macroglia – astrocytes and Müller cells – on the development of AMD-like retinopathy, we performed analysis of the dynamics of age-related changes in the expression of glial fibrillary acidic protein (GFAP; an intermediate-filament protein) in OXYS and Wistar rats at different ages (20 days, 3, 7 and 18 months; Fig. 5A). Here, GFAP is linked to retinal disorder.