More importantly, synaptic relocation of GLUN2B-containing NMDARs mediated by FTY720 might have direct impact on synaptic plasticity and memory processes and underlie the increase in cognitive performance observed in AD mice after drug treatment (this study Supplementary Fig. 1; Asle-Rousta, 2013 #696}43, 44. The gene discussed is GRIN2B; the disease is Alzheimer disease.